Ca2+-SENSING RECEPTOR MUTATIONS IN SPORADIC HYPOPARATHYROIDISM.• 507
نویسندگان
چکیده
منابع مشابه
Prevalence of calcium sensing receptor autoantibodies in patients with sporadic idiopathic hypoparathyroidism.
OBJECTIVE The pathogenesis of sporadic idiopathic hypoparathyroidism is unclear. The calcium sensing receptor (CaSR) plays a pivotal role in extracellular calcium homeostasis and is the candidate autoantigen in hypoparathyroidism associated with autoimmune polyglandular endocrinopathy syndrome. We therefore looked for antibodies (Ab) against the CaSR in patients with sporadic idiopathic hypopar...
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Familial hypoparathyroidism (also termed autosomal dominant hypocalcemia) is characterized by hypocalcemia, hyperphosphatemia, and relative hypercalciuria, particularly during treatment with vitamin D and calcium to correct the hypocalcemia. Serum parathyroid hormone is inappropriately suppressed. Over 30 activating missense mutations in the calcium-sensing receptor gene have been identified in...
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The extracellular calcium (Ca(2+)(o))-sensing receptor (CaR) recognizes and responds to (i.e., "senses") Ca(2+)(o) as its principal physiological ligand. In the present studies, we document that the CaR is activated not only by extracellular calcium ions but also by amino acids, establishing its capacity to sense nutrients of two totally different classes. l-Amino acids, especially aromatic ami...
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BACKGROUND Remission of disease activity is a characteristic feature of autoimmune endocrine disorders such as Graves' disease, Addison's disease and occasionally in patients with premature ovarian failure. Autoimmunity is also implicated in sporadic idiopathic hypoparathyroidism (SIH) with clinical remission of disease reported in three cases. OBJECTIVE To assess the rate of remission in pat...
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n engl j med 368;26 nejm.org june 27, 2013 2532 of a meta-analysis of studies of the effect of reduced dietary salt on the incidence of cardiovascular events and death.1 The authors of the Cochrane report wrote that there was “no strong evidence of benefit.” In a summary statement, we wrote that this particular Cochrane analysis concluded that reducing dietary salt intake did not decrease the r...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1996
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-199604001-00527